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In severe cases, it can affect mental health, resulting in depression or even cognitive decline

212 LiuZ.JiangM.KangT.MiaoD.GuG.SongQ.et al (2013b)

Tsuchiyama et al., Enhanced Longevity by Ibuprofen, Conserved in Multiple Species, Occurs in Yeast through Inhibition of Tryptophan Import, PLOS Genetics, 2014, 18;10(12):e1004860